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Remarkable progress in the past decade has been madein the discovery of novel chemotherapeutic drugs that selectively activate p53 totrigger rapid elimination of tumors by targeting the p53-MDM2-MDMX loop. Pulsesshould be felt in extremities, assessing the radial, brachial, andfemoral pulses bilaterally

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While these eventsare occurring, one or several blood vessels grow throughthe thin diaphyseal bony collar to vascularize the cavity (seeillustration 4 ofFig. Leg vein thrombosis and pulmonaryembolism: The older preparations increased theincidence of venous thromboembolism, but thisis found to be only marginal with the newerreduced steroid content pills

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